Student projects at IGP
IGP offers projects for students at different education programmes. Below you can find summaries of currently available projects in the research areas cancer/oncology, vascular biology, molecular tools, genetics and genomics, pathology, radiation sciences and immunology.
Click on the title of the project you are interested in to get to a more detailed description including the contact details of the supervisor of the project. For further information please contact the supervisor.
Are you researcher and would you like to announce a project? Please fill in this project formand send to Kristin.Peisker@igp.uu.se.
Project courses at IGP are offered as 7.5, 15 or 30 credit courses.
For students interested in these courses:
Please apply by filling in the Project Plan Form. Note that you have to agree on a project with your supervisor to be eligible for the course. Apply for the course at antagning.se. Do not forget to upload the filled form with your application.
If you - as a supervisor - accept a student not enrolled on a Master`s programme or project course at IGP for a project or internship in you lab please fill in the following "Lab project verification form". More details are given in the form.
Projects in the research area cancer/oncology
Identification of long non-protein-coding RNAs collaborating with PRC2 in MM Multiple myeloma (MM) despite becoming increasingly treatable remains to date incurable and accounts for the second most common hematological cancer. This warrants innovative approaches into tackling the disease overtly complex genetic background. Our research aims is to identify interacting partners with the Polycomb group proteins by RNA immunoprecipitation coupled with next generation sequencing (RIP-seq, CLIP seq or iCLIP) in MM cell lines and primary MM samples. We also aim to identify the genome-specific binding of lncRNAs of interest by chromatin isolation via RNA precipitation (ChIRP) assays coupled to next generation sequencing and mass spectrometry.
The in situ immune profiling of solid tumors
The effect of anti-tumor immunotherapy is very heterogeneous and only a minor fraction of patients benefits from this therapy. We will characterize immune infiltrate in major solid cancers and investigate infiltration patterns of different immune cell classes, enabling a detailed classification of different tumor types according to their immunological status.
The role of the lymph node vasculature in tumour metastasis and anti-tumour immunity
The lymph nodes have essential roles in adaptive immune responses, including anti-tumour immune responses, and are major sites for tumour metastasis. Our group is interested in the stromal changes that occur in the tumour draining lymph nodes and particularly the changes of the vasculature and how this affect tumour metastasis and anti-tumour immune responses.
Investigating new immunotherapy combinations for the treatment of bladder cancer
Localized bladder cancer can be treated with locally administrated BCG or chemotherapy delivered into the bladder lumen. However tumor recurrence is high for both local and metastatic disease. Our research focuses on studying how combinations of locally administrated immunotherapies can aid a systemic anti-tumor response so that metastatic disease is also prevented.
Investigating adaptive immune responses in human whole blood
Efficacy, toxicity and cytokine release are parameters important to study with novel immunotherapies. This project will modify/improve existing methods in order to advance the field of cytokine release/immune toxicity technologies. Techniques that will be used are flow cytometry, Q-PCR and ELISA based technologies.
Clinical or translational research on adult cancer cases in U-CAN
Clinical data gathering or sample analyses based on the cancer cases included in U-CAN followed by hypothesis testing.
Extracellular matrix interactions of importance for brain tumour formation and neural development
In our projects we incorporate experience of neural stem cells with glioma biology, leveraging the close relationship between these two fields. We also investigate the neuro-inflammatory responses to brain tumours.
Investigations of cancer stem cells in the brain cancer glioblastoma
Glioblastoma is the most common and deadly primary brain cancer. Our research aims at identifying mechanisms governing progression and recurrence, with focus on the cancer stem cells. We use patient-derived cell cultures and mouse models, and the goal is to find novel therapeutic targets in glioblastoma.
Finding and understanding somatic mutations and their contribution to development of colorectal cancer
We are looking for students with an interest in functional studies or genetics of cancer, or in development of computer tools for large sequence data analysis.
New treatment for brain tumors: Sensitization of multi-resistant glioblastoma clones
Gliobastoma multiforme is the most malignant primary brain tumor. The cancer cells vary between more treatment-resistant and more treatment-sensitive cell-states. Current studies aim to uncover forces that drives these changes in treatment resistance and make all cells vulnerable to therapy.
Projects in the research area vascular biology
The role of Tie2 signalling in kidney fibrosis
The project involves the vascular factor Tie2 and how it affects the development of fibrosis in kidney. You will have the opportunity to learn tissue dissection, immunofluorescence staining, confocal imaging, image analysis and molecular biology, including RNA preparation and real time PCR.
Deciphering the cellular effects of edema on the vasculature
The project tests the hypothesis that increased interstitial pressure leads to specific cytoskeletal and junctional rearrangements in endothelial cells to adjust the balance between vascular leakage and lymphatic drainage, which is prerequisite for normal vascular development and function.
Elucidating organ-specific mechanisms of development and disease within the lymphatic vasculature
The project investigates mechanisms of lymphatic vascular development in different organs and provides insight into tissue-specific functional specialization and disease manifestation within the vasculature. We focus on characterizing organ-specific endothelial progenitor cells using genetic mouse models, microscopy and single-cell transcriptomics.
Regulatory Roles of Long Non-coding RNAs during Blood Brain Barrier development under normal and disease condition
In this project, we will analyze differential expression of long non-coding RNAs in endothelial cells between different regions of mouse brain, during blood brain barrier maturation and under normal or disease condition.
Projects in the research area Molecular Tools
New approaches for molecular diagnostics
Molecular diagnostics will increasingly impact medical practice. Our group develops, applies, and disseminates advanced molecular tools for diagnostic analyses of nucleic acids and proteins in situ and in solution. We welcome students interested in helping us expand the range of molecular analyses possible, or find compelling biomedical applications of these methods.
Methods for RNA and protein analysis in single cells
The Molecular Tools group and the SciLifeLab Single Cell Proteomics Facility are developing methods to study RNA and protein in multiplex at the level of the single cell.
Projects in the research area Genetics and genomics
Projects in the research area Pathology
Projects in the research area Radiation Sciences
Projects in the research area Immunology
Dissect the negative immune regulatory network to improve cancer immunotherapy
We will form a highly interdisciplinary team between IGP and SciLifeLab to investigate the function of negative immune regulatory pathways in controlling response to cancer immunotherapy. Subsequent PhD positions or project extensions may be possible upon funding availability.
T cell responses to Herpes simplex virus type 1 in Alzheimer’s disease
Reactivated Herpes simplex virus type 1 (HSV1) infection has been linked to increased risk of Alzheimer’s disease (AD). Virus-specific T cells are involved in the prevention of HSV1 reactivations. This mechanism could be disturbed in AD, either by allowing more frequent reactivation, leading to increased exposure to active virus, or by overactivation, contributing to inflammation-mediated neurodegeneration. Little is known of the role of the peripheral immune system in AD development, but immunosenescence of T cells could play a role. The overall aim is to investigate if HSV1-specific T cell immunity differs between AD patients and non-demented controls.