Protein biomarkers protect against disease development


A comprehensive study from IGP shows that several disease-associated protein biomarkers protect healthy individuals from developing inflammatory diseases. The protective effects are attributed to the proteins’ function in preventing tissue damage, a function that might be very different from the effect in a tissue subjected to chronic or acute inflammation.

Inflammatory processes are associated with a large range of human diseases, including rheumatic diseases and allergies. A large number of proteins are known to be associated with inflammatory disease but the causal relationship between a protein biomarker and inflammatory diseases ha generally not been clarified.

In the present study, researchers in Åsa Johansson’s group have used genetic information to identify protein biomarkers that cause or protect against disease and they found proteins that for instance protected against psoriasis, osteoarthritis and ulcerative colitis. The results suggest that, in healthy individuals, such proteins are expressed to protect against tissue damage.

More information:
News item, Uppsala University
Research in Åsa Johansson’s group
Research article in Science Advances

Last modified: 2022-01-26