Publications Linda Holmfeldt

Publications in PubMed
 

Selected publications:

  1. Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi SRK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui C-H, Myers RM, Guy RK, Kanneganti T-D, Relling MV, and Evans WE. NALP3 Inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells. Nat Genet. 47(6):607-14 (2015).
     
  2. Chen X, Gupta P, Wang J, Nakitandwe J, Roberts K, Dalton JD, Parker M, Patel S, Holmfeldt L, Payne D, Easton J, Ma J, Rusch M, Wu G, Patel A, Baker S, Dyer MA, Shurtleff A, Espy S, Pounds S, Downing JR, Ellison D, Mullighan CG, and Zhang J. CONSERTING: an accurate method for detecting somatic DNA copy number alterations in whole genome sequencing data. Nature Methods. 12(6):527-30 (2015).
     
  3. Holmfeldt L and Mullighan CG. Generation of human acute lymphoblastic leukemia xenografts for use in oncology drug discovery. Curr Protoc Pharmacol. 68:14.32.1-14.32.19 (2015).
     
  4. Andersson AK, Ma J, Wang J, Chen X, Larson-Gedman A, Dang J, Nakitandwe J, Holmfeldt L, Parker M, Easton J, Huether R, Kriwacki R, Rusch M, Wu G, Li Y, Mulder H, Raimondi S, Pounds S, Guolian K, Shi L, Becksfort J, Gupta P, Payne-Turner D, Vadodaria B, Boggs K, Yergeau D, Manne J, Song G, Edmonson M, Nagawatte P, Wei L, Cheng C, Pei D, Sutton R, Venn NC, Chetcuti A, Rush A, Catchpoole D, Heldrup J, Fioretos T, Lu C, Ding L, Pui CH, Shurtleff S, Mullighan CG, Mardis ER, Wilson RK, Gruber TA, Zhang J, and Downing JR, for the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project. The landscape of somatic mutations in Infant MLL-rearranged acute lymphoblastic leukemias. Nat Genet. 47(4):330-7 (2015).
     
  5. Ntziachristos P, Tsirigos A, Welstead GG, Trimarchi T, Bakogianni S, Xu L, Loizou E, Holmfeldt L, Strikoudis A, King B, Mullenders J, Becksfort J, Nedjic J, Paietta E, Tallman MS, Rowe JM, Tonon G, Satoh T, Kruidenier L, Prinjha R, Akira S, Van Vlierberghe P, Ferrando AA, Jaenisch R, Mullighan CG, and Aifantis I. Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukemia. Nature. 514(7523):513-7 (2014).
     
  6. Holmfeldt L*, Wei L*, Diaz-Flores E, Zhang J, Walsh M, Zhang J, Ding L, Payne-Turner D, Churchman M, Andersson A, Chen SC, McCastlain K, Becksfort J, Ma J, Wu G, Patel SN, Heatley SL, Phillips LA, Song G, Easton J, Parker M, Chen X, Rusch M, Boggs K, Vadodaria B, Hedlund E, Drenberg C, Baker S, Pei D, Cheng C, Huether R, Lu C, Fulton RS, Fulton LL, Tabib Y, Dooling DJ, Ochoa K, Minden M, Lewis ID, To LB, Marlton P, Roberts AW, Raca G, Stock W, Neale G, Drexler HG, Dickins RA, Ellison DW, Shurtleff SA, Pui CH, Ribeiro RC, Devidas M, Carroll AJ, Heerema NA, Wood B, Borowitz MJ, Gastier-Foster JM, Raimondi SC, Mardis ER, Wilson RK, Downing JR, Hunger SP, Loh ML, Mullighan CG. The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet. 45(3):242-52 (2013). *Equal contribution
     
  7. Zhang J*, Ding L*, Holmfeldt L*, Wu G, Heatley SL, Payne-Turner D, Easton, J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR and Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukemia. Nature. 481(7380):157-63 (2012). *Equal contribution
     
  8. Berquam-Vrieze KE, Nannanpaneni K, Brett BT, Holmfeldt L, Ma J, Zagorodna O, Jenkins NA, Copeland NG, Meyerholz DK, Knudson CM, Mullighan CG, Scheetz TE and Dupuy AJ. Cell of origin strongly influences genetic selection in mouse models of T-ALL. Blood. 118(17):4646-56 (2011).
     
  9. Wang J, Mullighan CG, Easton J, Roberts S, Ma J, Rusch MC, Chen K, Harris CC, Ding L, Heatley SL, Holmfeldt L, Payne-Turner D, Fan X, Wei L, Zhao D, Obenauer JC, Naeve C, Mardis ER, Wilson RK, Downing JR, and Zhang J. CREST: an algorithm that directly maps structural variations for next-generation sequencing data. Nature Methods. 8(8):652-4 (2011).
     
  10. Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL, Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui C-H, Baker SD, Brindle PK, and Downing JR. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature. 471(7337):235-9 (2011).