Publications in DiVA – Olle Korsgren

  • Nano, Rita; Kerr-Conte, Julie A.; Scholz, Hanne; Engelse, Marten et al.

    Heterogeneity of Human Pancreatic Islet Isolation Around Europe: Results of a Survey Study

    Part of Transplantation, p. 190-196, 2020.

  • Skog, Oskar; Korsgren, Olle

    On the dynamics of the human endocrine pancreas and potential consequences for the development of type 1 diabetes

    Part of Acta Diabetologica, p. 503-511, 2020.

    Open access
  • Maffi, Paola; Lundgren, Torbjorn; Tufveson, Gunnar; Rafael, Ehab et al.

    Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes

    Part of Diabetes Care, p. 710-718, 2020.

  • Helker, Christian S M; Mullapudi, Sri-Teja; Mueller, Laura M; Preussner, Jens et al.

    A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development.

    Part of Development, 2019.

  • Seiron, Peter; Wiberg, Anna; Kuric, Enida; Krogvold, Lars et al.

    Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced

    Part of The journal of pathology. Clinical research, p. 248-255, 2019.

    Open access
  • Stenwall, Anton; Ingvast, Sofie; Skog, Oskar; Korsgren, Olle

    Characterization of host defense molecules in the human pancreas

    Part of Islets, p. 89-101, 2019.

    Open access
  • Bergström, Marcus; Müller, Malin; Karlsson, Marie; Scholz, Hanne et al.

    Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells

    Part of Cell Transplantation, p. 1603-1613, 2019.

    Open access
  • Brandhorst, Heide; Johnson, Paul R.; Moench, Johanna; Kurfuerst, Manfred et al.

    Comparison of Clostripain and Neutral Protease as Supplementary Enzymes for Human Islet Isolation

    Part of Cell Transplantation, p. 176-184, 2019.

    Open access
  • Korsgren, Olle; Skyler, Jay S; Skog, Oskar; Sundberg, Frida et al.

    Imagining a better future for all people with type 1 diabetes mellitus

    Part of Nature Reviews Endocrinology, p. 623-624, 2019.

  • Nano, Rita; Kerr-Conte, Julie A.; Bosco, Domenico; Karlsson, Marie et al.

    Islets for Research: Nothing Is Perfect, but We Can Do Better

    Part of Diabetes, p. 1541-1543, 2019.

  • Skog, Oskar; Klingel, Karin; Roivainen, Merja; Korsgren, Olle

    Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence

    Part of Diabetologia, p. 1097-1099, 2019.

  • von Zur-Mühlen, Bengt; Lundgren, Torbjorn; Bayman, Levent; Berne, Christian et al.

    Open Randomized Multicenter Study to Evaluate Safety and Efficacy of Low Molecular Weight Sulfated Dextran in Islet Transplantation

    Part of Transplantation, p. 630-637, 2019.

    Open access
  • Jonsson, Alexander; Yngve, Erik; Karlsson, Marie; Ingvast, Sofie et al.

    Protein Kinase R Is Constitutively Expressed in the Human Pancreas

    Part of Journal of Histochemistry and Cytochemistry, p. 99-105, 2019.

  • Weis, Jan; Ahlström, Håkan; Korsgren, Olle

    Proton MR spectroscopy of human pancreas allografts

    Part of Magnetic Resonance Materials in Physics, Biology and Medicine, p. 511-517, 2019.

    Open access
  • Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

    Synthesis and preclinical evaluation of the CRTH2 antagonist [11C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

    Part of Nuclear Medicine and Biology, p. 1-10, 2019.

    Open access
  • Korsgren, Olle; Skog, Oskar; Ludvigsson, Johnny

    Teplizumab in Relatives at Risk for Type 1 Diabetes

    Part of New England Journal of Medicine, p. 1879-1880, 2019.

  • Skog, Oskar; Korsgren, Olle

    Aetiology of type 1 diabetes: Physiological growth in children affects disease progression

    Part of Diabetes, obesity and metabolism, p. 775-785, 2018.

  • Eich, Torsten; Ståhle, Magnus U.; Gustafsson, Bengt; Horneland, Rune et al.

    Calcium: A Crucial Potentiator for Efficient Enzyme Digestion of the Human Pancreas

    Part of Cell Transplantation, p. 1031-1038, 2018.

    Open access
  • Gotthardt, Martin; Eizirik, Decio L.; Aanstoot, Henk-Jan; Korsgren, Olle et al.

    Detection and quantification of beta cells by PET imaging: why clinical implementation has never been closer

    Part of Diabetologia, p. 2516-2519, 2018.

  • Lundberg, Marcus; Stenwall, Per-Anton; Tegehall, Angelica; Korsgren, Olle et al.

    Expression profiles of stress-related genes in islets from donors with progressively impaired glucose metabolism.

    Part of Islets, p. 69-79, 2018.

  • Eriksson, Olof; Johnström, Peter; Cselenyi, Zsolt; Jahan, Mahabuba et al.

    In Vivo Visualization of beta-Cells by Targeting of GPR44

    Part of Diabetes, p. 182-192, 2018.

  • Abadpour, Shadab; Halvorsen, Bente; Sahraoui, Afaf; Korsgren, Olle et al.

    Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT

    Part of Journal of Molecular Endocrinology, p. 171-183, 2018.

  • Fuchs, Anke; Gliwiński, Mateusz; Grageda, Nathali; Spiering, Rachel et al.

    Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

    Part of Frontiers in Immunology, 2018.

    Open access
  • Kuric, Enida; Krogvold, Lars; Hanssen, Kristian F.; Dahl-Jorgensen, Knut et al.

    No Evidence for Presence of Mucosal-Associated Invariant T Cells in the Insulitic Lesions in Patients Recently Diagnosed with Type 1 Diabetes

    Part of American Journal of Pathology, p. 1744-1748, 2018.

  • Eriksson, Olof; Korsgren, Olle; Selvaraju, Ram Kumar; Mollaret, Marjorie et al.

    Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8: a direct comparison with radio-iodinated Exendin-4

    Part of Acta Diabetologica, p. 49-57, 2018.

    Open access
  • Vågesjö, Evelina; Seignez, Cedric; Christoffersson, Gustaf; Herrera Hidalgo, Carmen et al.

    Perivascular macrophages regulate blood flow following tissue damage

    Part of European Journal of Clinical Investigation, p. 44-45, 2018.

  • Jahan, Mahabuba; Johnström, Peter; Selvaraju, Ramkumar; Svedberg, Marie et al.

    The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass.

    Part of EJNMMI Research, 2018.

    Open access
  • Stenwall, Anton; Seiron, Peter; Lundberg, Marcus; Esguerra, Jonathan et al.

    Transcriptional analysis of islets of Langerhans from organ donors of different ages

    2018.

  • Carlsson, Per-Ola; Espes, Daniel; Sedigh, Amir; Rotem, Avi et al.

    Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

    Part of American Journal of Transplantation, p. 1735-1744, 2018.

    Open access
  • Carlbom, Lina; Espes, Daniel; Lubberink, Mark; Martinell, Mats et al.

    [(11)C]5-Hydroxy-Tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes

    Part of Diabetes, p. 1286-1292, 2017.

  • Radenkovic, M; Uvebrant, K; Skog, Oskar; Sarmiento, L et al.

    Characterization of resident lymphocytes in human pancreatic islets

    Part of Clinical and Experimental Immunology, p. 418-427, 2017.

  • Skog, Oskar; Korsgren, Olle

    Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334-1345

    Part of Diabetes, p. e8-e9, 2017.

  • Schive, Simen W.; Foss, Aksel; Sahraoui, Afaf; Kloster-Jensen, Kristine et al.

    Cost and clinical outcome of islet transplantation in Norway 2010-2015

    Part of Clinical Transplantation, 2017.

  • Kuric, Enida; Seiron, Peter; Krogvold, Lars; Edwin, Bjørn et al.

    Demonstration of Tissue Resident Memory CD8 T Cells in Insulitic Lesions in Adult Patients with Recent-Onset Type 1 Diabetes

    Part of American Journal of Pathology, p. 581-588, 2017.

  • Kabra, Uma D; Pfuhlmann, Katrin; Migliorini, Adriana; Keipert, Susanne et al.

    Direct Substrate Delivery into Mitochondrial-Fission Deficient Pancreatic Islets Rescues Insulin Secretion

    Part of Diabetes, p. 1247-1257, 2017.

  • Abadpour, Shadab; Göpel, Sven O.; Schive, Simen W.; Korsgren, Olle et al.

    Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis

    Part of Scientific Reports, 2017.

    Open access
  • Schive, Simen W.; Mirlashari, Mohammad Reza; Hasvold, Grete; Wang, Mengyu et al.

    Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo

    Part of Cell Medicine, p. 103-116, 2017.

  • Lundberg, Marcus; Seiron, Peter; Ingvast, Sofie; Korsgren, Olle et al.

    Insulitis in human diabetes: a histological evaluation of donor pancreases

    Part of Diabetologia, p. 346-353, 2017.

    Open access
  • Korsgren, Olle

    Islet Encapsulation: Physiological Possibilities and Limitations

    Part of Diabetes, p. 1748-1754, 2017.

  • Brandhorst, Daniel; Parnaud, Geraldine; Friberg, Andrew; Lavallard, Vanessa et al.

    Multicenter Assessment of Animal-free Collagenase AF-1 for Human Islet Isolation

    Part of Cell Transplantation, p. 1688-1693, 2017.

    Open access
  • Horneland, R.; Guvag, S.; Korsgren, Olle; Aandahl, E.

    Pancreatectomy and Islet Autotransplantation After Combined Split Liver Transplantation and Pancreaticoduodenectomy: A Case Report

    Part of American Journal of Transplantation, p. 693-694, 2017.

  • Carlbom, Lina; Weis, Jan; Johansson, Lars; Korsgren, Olle et al.

    Pre-transplantation ³¹P-magnetic resonance spectroscopy for quality assessment of human pancreatic grafts: A feasibility study

    Part of Magnetic Resonance Imaging, p. 98-102, 2017.

  • Brandhorst, Heide; Johnson, Paul R. V.; Korsgren, Olle; Brandhorst, Daniel

    Quantifying the Effects of Different Neutral Proteases on Human Islet Integrity

    Part of Cell Transplantation, p. 1733-1741, 2017.

    Open access
  • Lundberg, Marcus; Seiron, Peter; Ingvast, Sofie; Korsgren, Olle et al.

    Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary? Reply to Campbell-Thompson ML, Atkinson MA, Butler AE et al [letter].

    Part of Diabetologia, p. 756-757, 2017.

  • Korsgren, Erik; Korsgren, Olle

    An Apparent Deficiency of Lymphatic Capillaries in the Islets of Langerhans in the Human Pancreas

    Part of Diabetes, p. 1004-1008, 2016.

  • Domsgen, Erna; Lind, Katharina; Kong, Lingjia; Huhn, Michael H. et al.

    An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets

    Part of Scientific Reports, 2016.

    Open access
  • Rydén, Anneli; Nyman, Gorel; Nalin, Lovisa; Andreasson, Susanne et al.

    Cardiovascular side-effects and insulin secretion after intravenous administration of radiolabeled Exendin-4 in pigs

    Part of Nuclear Medicine and Biology, p. 397-402, 2016.

  • Hårdstedt, Maria; Lindblom, Susanne; Karlsson-Para, Alex; Nilsson, Bo et al.

    Characterization of innate immunity in an extended whole blood model of human islet allotransplantation

    Part of Cell Transplantation, p. 503-515, 2016.

  • Brandhorst, Heide; Kurfuerst, Manfred; Johnson, Paul R.; Korsgren, Olle et al.

    Comparison of Neutral Proteases and Collagenase Class I as Essential Enzymes for Human Islet Isolation

    Part of TRANSPLANTATION DIRECT, 2016.

    Open access
  • Ståhle, Magnus; Foss, Aksel; Gustafsson, Bengt; Lempinen, Marko et al.

    Evaluation of Perfluorohexyloctane/Polydimethylsiloxane for Pancreas Preservation for Clinical Islet Isolation and Transplantation

    Part of Cell Transplantation, p. 2269-2276, 2016.

    Open access
  • Markmann, James F.; Bartlett, Stephen T.; Johnson, Paul; Korsgren, Olle et al.

    Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of beta-Cell Replacement

    Part of Transplantation, p. E25-E31, 2016.

  • von Herrath, M. G.; Korsgren, Olle; Atkinson, M. A.

    Factors impeding the discovery of an intervention-based treatment for type 1 diabetes

    Part of Clinical and Experimental Immunology, p. 1-7, 2016.

  • Cooper, David K. C.; Bottino, Rita; Gianello, Pierre; Graham, Melanie et al.

    First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial

    Part of Xenotransplantation, p. 46-52, 2016.

  • Korsgren, Erik; Korsgren, Olle

    Glucose Effectiveness: The Mouse Trap in the Development of Novel beta-Cell Replacement Therapies

    Part of Transplantation, p. 111-115, 2016.

  • Hellström-Lindahl, Ewa; Danielsson, Angelika; Pontén, Fredrik; Czernichow, Paul et al.

    GPR44 is a pancreatic protein restricted to the human beta cell

    Part of Acta Diabetologica, p. 413-421, 2016.

  • Bader, Erik; Migliorini, Adriana; Gegg, Moritz; Moruzzi, Noah et al.

    Identification of proliferative and mature beta-cells in the islets of Langerhans

    Part of Nature, p. 430-+, 2016.

  • Krogvold, Lars; Wiberg, Anna; Edwin, Bjørn; Buanes, Trond et al.

    Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes

    Part of Diabetologia, p. 492-501, 2016.

  • Ricordi, Camillo; Goldstein, Julia S.; Balamurugan, A. N.; Szot, Gregory L. et al.

    National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

    Part of Diabetes, p. 3418-3428, 2016.

  • Carlbom, Lina; Espes, Daniel; Lubberink, Mark; Eriksson, Olof et al.

    Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes

    Part of Diabetologia, p. 1968-1972, 2016.

  • Hering, Bernhard J.; Clarke, William R.; Bridges, Nancy D.; Eggerman, Thomas L. et al.

    Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

    Part of Diabetes Care, p. 1230-1240, 2016.

  • Eriksson, Olof; Selvaraju, Ramkumar; Eich, Torsten; Willny, Mariam et al.

    Positron Emission Tomography to assess the outcome of intraportal islet transplantation

    Part of Diabetes, p. 2482-2489, 2016.

  • Bartlett, Stephen T.; Markmann, James F.; Johnson, Paul; Korsgren, Olle et al.

    Report from IPITA-TTS Opinion Leaders Meeting on the Future of beta-Cell Replacement

    Part of Transplantation, p. S1-S44, 2016.

    Open access
  • Kloster-Jensen, Kristine; Sahraoui, Afaf; Vethe, Nils Tore; Korsgren, Olle et al.

    Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids

    Part of Journal of Diabetes Research, 2016.

    Open access
  • Davies, Lindsay C.; Alm, Jessica J.; Heldring, Nina; Moll, Guido et al.

    Type 1 Diabetes Mellitus Donor Mesenchymal. Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro

    Part of Stem Cells Translational Medicine, p. 1485-1495, 2016.

  • Hårdstedt, Maria; Lindblom, Susanne; Hong, Jaan; Nilsson, Bo et al.

    A novel model for studies of blood-mediated long-term responses to cellular transplants

    Part of Upsala Journal of Medical Sciences, p. 28-39, 2015.

  • Wiberg, Anna; Granstam, Anna; Ingvast, Sofie; Harkonen, T. et al.

    Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies

    Part of Clinical and Experimental Immunology, p. 278-288, 2015.

  • Ståhle, Magnus; Foss, Aksel; Gustafsson, Bengt; Lempinen, Marko et al.

    Clostripain, the Missing Link in the Enzyme Blend for Efficient Human Islet Isolation

    Part of Transplantation Direct, p. 1-6, 2015.

  • Krogvold, Lars; Edwin, Bjørn; Buanes, Trond; Frisk, Gun et al.

    Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes

    Part of Diabetes, p. 1682-1687, 2015.

  • Skog, Oskar; Korsgren, Stella; Wiberg, Anna; Danielsson, Angelika et al.

    Expression of Human Leukocyte Antigen Class I in Endocrine and Exocrine Pancreatic Tissue at Onset of Type 1 Diabetes

    Part of American Journal of Pathology, p. 129-138, 2015.

  • Krogvold, Lars; Skog, Oskar; Sundström, Görel; Edwin, Bjorn et al.

    Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro: Results From the DiViD Study

    Part of Diabetes, p. 2506-2512, 2015.

  • Schive, Simen W.; Scholz, Hanne; Sahraoui, Afaf; Kloster-Jensen, Kristine et al.

    Graft function 1 year after pregnancy in an islet-transplanted patient

    Part of Transplant International, p. 1235-1239, 2015.

  • Nano, Rita; Bosco, Domenico; Kerr-Conte, Julie A.; Karlsson, Marie et al.

    Human islet distribution programme for basic research: activity over the last 5 years

    Part of Diabetologia, p. 1138-1140, 2015.

  • Hansson, S. F.; Vachet, P.; Hammar, M.; Korsgren, Olle et al.

    Identification of potential circulating beta cell biomarkers

    Part of Diabetologia, p. S149-S150, 2015.

  • Vågesjö, Evelina; Christoffersson, Gustaf; Waldén, Tomas B; Carlsson, Per-Ola et al.

    Immunological shielding by induced recruitment of regulatory T lymphocytes delays rejection of islets transplanted to muscle

    Part of Cell Transplantation, p. 263-276, 2015.

  • Vågesjö, Evelina; Christoffersson, Gustaf; Waldén, Tomas B; Carlsson, Per-Ola et al.

    Immunological Shielding by Induced Recruitment of Regulatory T-Lymphocytes Delays Rejection of Islets Transplanted in Muscle

    Part of Cell Transplantation, p. 263-276, 2015.

  • Simonson, Oscar E.; Mougiakakos, Dimitrios; Heldring, Nina; Bassi, Giulio et al.

    In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome

    Part of Stem Cells Translational Medicine, p. 1199-1213, 2015.

  • Kloster-Jensen, Kristine; Vethe, Nils Tore; Bremer, Sara; Abadpour, Shadab et al.

    Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets invitro

    Part of Transplant International, p. 1152-1161, 2015.

  • Fransson, Moa; Brännström, Johan; Duprez, Ida; Essand, Magnus et al.

    Mesenchymal stromal cells supportendothelial cell interactions in anintramuscular islet transplantation model

    Part of Regenerative Medicine Research, 2015.

    Open access
  • Carlsson, Per-Ola; Korsgren, Olle; Le Blanc, Katarina

    Mesenchymal Stromal Cells to Halt the Progression of Type 1 Diabetes?

    Part of Current Diabetes Reports, 2015.

  • Carlsson, Per-Ola; Schwarcz, Erik; Korsgren, Olle; Le Blanc, Katarina

    Preserved Beta-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells

    Part of Diabetes, p. 587-592, 2015.

  • Goto, Masafumi; Friberg, Andrew; Ståhle, Magnus; Imura, Takehiro et al.

    Proof of concept for the clinical application of animal component free recombinant collagenase for isolating pancreatic islets

    Part of Xenotransplantation, p. S50-S50, 2015.

  • Goto, Masafumi; Friberg, Andrew; Ståhle, Magnus; Imura, Takehiro et al.

    Proof Of Concept For The Clinical Application Of Animal Component Free Recombinant Collagenase For Isolating Pancreatic Islets

    Part of Transplantation, p. S80-S80, 2015.

  • Jahan, M.; Johnstrom, P.; Nag, S.; Takano, A. et al.

    Synthesis and biological evaluation of [C-11]AZ12504948; a novel tracer for imaging of glucokinase in pancreas and liver

    Part of Nuclear Medicine and Biology, p. 387-394, 2015.

  • Sahraoui, Afaf; Winzell, Maria Soerhede; Gorman, Tracy; Smith, Dave M. et al.

    The Effects of Exendin-4 Treatment on Graft Failure: An Animal Study Using a Novel Re-Vascularized Minimal Human Islet Transplant Model

    Part of PLoS ONE, 2015.

    Open access
  • Ricordi, C.; Hering, B.; Bridges, N.; Eggerman, T. et al.

    Completion of the First FDA Phase 3 Multicenter Trial of Islet Transplantation in Type 1 Diabetes by the NIH CIT Consortium

    Part of Cytotherapy, p. S14-S14, 2014.

  • Eriksson, Olof; Velikyan, Irina; Selvaraju, Ram K; Kandeel, Fouad et al.

    Detection of Metastatic Insulinoma by Positron Emission Tomography with [(68)Ga]Exendin-4 -: a case report

    Part of Journal of Clinical Endocrinology and Metabolism, p. 1519-1524, 2014.

  • Eriksson, B.; Eriksson, O.; Velikyan, Irina; Selvaraju, R. et al.

    Detection of metastatic insulinoma by positron emission tomography with [68Ga]Exendin-4-a case report

    Part of Wiener Klinische Wochenschrift, p. S152-S152, 2014.

  • Lundberg, J.; Stone-Elander, S.; Zhang, X. -M; Korsgren, Olle et al.

    Endovascular Method for Transplantation of Insulin-Producing Cells to the Pancreas Parenchyma in Swine

    Part of American Journal of Transplantation, p. 694-700, 2014.

    Open access
  • Hillerdal, Victoria; Berglund, David; Boura, Vanessa; Jin, Chuan et al.

    Engineering Regulatory Cells With a T Cell Receptor for Controlled Activation

    Part of Molecular Therapy, p. S180-S180, 2014.

  • Skog, Oskar; Ingvast, Sofie; Korsgren, Olle

    Evaluation of RT-PCR and immunohistochemistry as tools for detection of enterovirus in the human pancreas and islets of Langerhans

    Part of Journal of Clinical Virology, p. 242-247, 2014.

  • Hopfgarten, Johan; Stenwall, Per-Anton; Wiberg, Anna; Anagandula, Mahesh et al.

    Gene expression analysis of human islets in a subject at onset of type 1 diabetes

    Part of Acta Diabetologica, p. 199-204, 2014.

  • Westman, Gabriel; Berglund, David; Widen, Johan; Ingelsson, Martin et al.

    Increased Inflammatory Response in Cytomegalovirus Seropositive Patients with Alzheimer's Disease

    Part of PLoS ONE, p. e96779-, 2014.

    Open access
  • Anagandula, Mahesh; Richardson, Sarah J.; Oberste, M. Steven; Sioofy-Khojine, Amir-Babak et al.

    Infection of Human Islets of Langerhans With Two Strains of Coxsackie B Virus Serotype 1: Assessment of Virus Replication, Degree of Cell Death and Induction of Genes Involved in the Innate Immunity Pathway

    Part of Journal of Medical Virology, p. 1402-1411, 2014.

  • Krogvold, Lars; Edwin, Bjorn; Buanes, Trond; Ludvigsson, Johnny et al.

    Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

    Part of Diabetologia, p. 841-843, 2014.

  • Selvaraju, Ram Kumar; Nalin, Lovisa; Velikyan, Irina; Berglund, Marie et al.

    PET imaging of the GLP-1 receptor in healthy and streptozotocin-induced diabetic pigs

    Part of Journal of Nuclear Medicine, p. 387-, 2014.

  • Selvaraju, Ram Kumar; Nalin, L.; Velikyan, Irina; Berglund, Marie et al.

    Positron Emission Tomography imaging of the glucagon like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs

    Part of European Journal of Nuclear Medicine and Molecular Imaging, p. S394-S394, 2014.

  • Nalin, Lovisa; Selvaraju, Ram K; Velikyan, Irina; Berglund, Marie et al.

    Positron emission tomography imaging of the glucagon-like peptide-1 receptor in healthy and streptozotocin-induced diabetic pigs

    Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 1800-1810, 2014.

  • Selvaraju, Ram Kumar; Velikyan, Irina; Asplund, Veronika; Johansson, Lars et al.

    Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma

    Part of Nuclear Medicine and Biology, p. 471-476, 2014.

  • Hulspas, Ruud; Villa-Komaroff, Lydia; Koksal, Erin; Etienne, Kenol et al.

    Purification of regulatory T cells with the use of a fully enclosed high-speed microfluidic system

    Part of Cytotherapy, p. 1384-1389, 2014.

  • Eriksson, Olof; Selvaraju, Ram K; Johansson, Lars; Eriksson, Jan W et al.

    Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas

    Part of Journal of Nuclear Medicine, p. 460-465, 2014.

  • Vågesjö, Evelina; Christoffersson, Gustaf; Korsgren, Olle; Essand, Magnus et al.

    Strategical steering of the immune system: induction of leukocyte vascular chaperoning increases functional blood flow responses in ischemic muscle

    Part of The FASEB Journal, 2014.

  • Danielsson, Angelika; Ponten, Fredrik; Fagerberg, Linn; Hallstrom, Bjorn M. et al.

    The Human Pancreas Proteome Defined by Transcriptomics and Antibody-Based Profiling

    Part of PLoS ONE, p. e115421-, 2014.

    Open access
  • Eriksson, Olof; Espes, Daniel; Selvaraju, Ram K; Jansson, Emma et al.

    The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas

    Part of Diabetes, p. 3428-3437, 2014.

  • Biglarnia, Ali-Reza; Bennet, William; Nilsson, Thomas; Larsson, Erik et al.

    Utilization of Small Pediatric Donors Including Infants for Pancreas and Kidney Transplantation: Exemplification of the Surgical Technique and the Surveillance

    Part of Annals of Surgery, p. e5-7, 2014.

  • Friberg, Andrew S.; Korsgren, Olle; Hellgren, Mikko

    A Vast Amount of Enzyme Activity Fails to Be Absorbed Within the Human Pancreas: Implications for Cost-Effective Islet Isolation Procedures

    Part of Transplantation, p. E36-E38, 2013.

  • Yu, Di; Jin, Chuan; Ramachandran, Mohanraj; Xu, Jing et al.

    Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

    Part of PLoS ONE, p. e54952-, 2013.

    Open access
  • Sjöberg, Lina; Biglarnia, Alireza; Ahlström, Håkan; Korsgren, Olle et al.

    Assessing the Viability of Human Pancreas Grafts using 31P MR Spectroscopy - a Pilot Study

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    Commercial Enzymes for Islet Isolation: Integrity and Degradation Over Time and Temperature

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    Cytomegalovirus-Specific CD4 and CD8 T Cell Responses in Infants and Children

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    Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer's Disease

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  • Hansson, Sara F.; Korsgren, Stella; Pontén, Fredrik; Korsgren, Olle

    Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins

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    Expanding the Donor Pool in Islet Transplantation: Age Impacts Parameters Regulating Glucose Metabolism

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    Functional Imaging of the Pancreatic Graft by Positron Emission Tomography

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    Ga-68-labelling of Exendin-4, preclinical evaluation of the resultant tracer for the imaging and quantification of insulinomas, and case patient examination

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    Human islet isolation processing times shortened by one hour: minimized incubation time between tissue harvest and islet purification

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    Human Islet Isolation Processing Times Shortened By One Hour: Minimized Incubation Time Between Tissue Harvest and Islet Purification

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    Human Islet Isolation Processing Times Shortened by One Hour: No Incubation Between Tissue Harvest and Isopycnic Islet Purification

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    Human Pancreatic Islet Preparations Release HMGB1: (Ir)Relevance for Graft Engraftment

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    Imaging the in vivo fate of human T cells following transplantation in immunoincompetent mice - Implications for clinical cell therapy trials

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    In Human Islets the Intracellular Concentration of Sirolimus Diminish when Combined with Tacrolimus, In Vitro.

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    In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with Ga-68-Labeled DO3A-Exendin-4

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    Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon-Treated Primary Human Pancreatic Islets

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    Islet Engraftment and Revascularization in Clinical and Experimental Transplantation

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  • Grapensparr, Liza; Vasylovska, Svitlana; Olerud, Johan; Korsgren, Olle et al.

    Neural Crest Stem Cells Induce Beta-cell Proliferation in Cultured and Transplanted Human Pancreatic Islets

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  • Berglund, David; Karlsson, Marie; Biglarnia, Ali-Reza; Lorant, Tomas et al.

    Obtaining regulatory T cells from uraemic patients awaiting kidney transplantation for use in clinical trials

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    Preliminary Results From Evaluation of an Innovative, Closed, Automated, Continuous Media Renewal System for Human Islets of Langerhans

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    Quality of Isolated Pig Islets Is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model

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  • Skog, Oskar; Korsgren, Stella; Melhus, Åsa; Korsgren, Olle

    Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease

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    Strategic recruitment of proangiogenic leukocytes to the ischemic hindlimb increases functional tissue perfusion

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    The diagnosis of insulitis in human type 1 diabetes

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    Treatment Efficacy and Immune Stimulation by AdCD40L Gene Therapy of Spontaneous Canine Malignant Melanoma

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  • Hodik, Monika; Lukinius, Agneta; Korsgren, Olle; Frisk, Gun

    Tropism Analysis of Two Coxsackie B5 Strains Reveals Virus Growth in Human Primary Pancreatic Islets but not in Exocrine Cell Clusters In Vitro

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    A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

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    Are Therapeutic Human Mesenchymal Stromal Cells Compatible with Human Blood?

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    Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction

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    Further Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts

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    gamma-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

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  • von Zur-Mühlen, Bengt; Tufveson, Gunnar; Korsgren, Olle

    Insulin independence after conversion from tacrolimus to cyclosporine in islet transplantation

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  • Berglund, David; Korsgren, Olle; Lorant, Tomas; Schneider, Karin et al.

    Isolation, expansion and functional assessment of CD4+CD25+FoxP3+ regulatory T cells and Tr1 cells from uremic patients awaiting kidney transplantation

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    Novel pancreatic beta cell-specific proteins: Antibody-based proteomics for identification of new biomarker candidates

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    On the etiology of type 1 diabetes: A new animal model signifying a decisive role for bacteria eliciting an adverse innate immunity response

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    Oxygen-charged HTK-F6H8 emulsion reduces ischemia: reperfusion injury in kidneys from brain-dead pigs

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    Pancreatic uptake of [68Ga]DO3A-Exendin4 is mediated by the GLP-1 receptor

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    Preclinical evaluation of a 68Ga-labeled biotin analogue for applications in islet transplantation

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    Proliferation and plasticity of human beta cells on physiologically occurring laminin isoforms

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    Transplanted functional islet mass: donor islet preparation, and recipitent factors influence early graft function in islet-after-kidney patients

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    Using HTK for Prolonged Pancreas Preservation Prior to Human Islet Isolation

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    Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment

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    Modulation of Innate Immunity in Human Pancreatic Islets Infected With Enterovirus In Vitro

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  • Ståhle, Magnus U.; Brandhorst, Daniel; Korsgren, Olle; Knutson, Folke

    Pathogen Inactivation of Human Serum Facilitates its Clinical Use for Islet Cell Culture and Subsequent Transplantation

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    Preparatory studies of composite mesenchymal stem cell islets for application in intraportal islet transplantation

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    The Instant Blood-Mediated Inflammatory Reaction Characterized in Hepatocyte Transplantation

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    A new oxygen carrier for improved long-term storage of human pancreata before islet isolation

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    Anchoring of vascular endothelial growth factor to surface-immobilized heparin on pancreatic islets: implications for stimulating islet angiogenesis

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    Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets

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    Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?

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    CMV-specific T-cell immunity, viral load, and clinical outcome in seropositive renal transplant recipients: a pilot study

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    Mammalian Tissue-Free Liberase: A New GMP-Graded Enzyme Blend for Human Islet Isolation

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    The Effect of Truncated Collagenase Class I Isomers on Human Islet Isolation Outcome

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    Antiviral effect of nicotinamide on enterovirus-infected human islets in vitro: effect on virus replication and chemokine secretion

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    Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization

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    Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo

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    Optimising islet engraftment is critical for successful clinical islet transplantation

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    Proceedings of "Pig-to-Man Islet Transplant Summit" held at the Nobel Forum, Stockholm, June 4-5, 2007

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    The ratio between collagenase class I and class II influences the efficient islet release from the rat pancreas

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    Antiviral Treatment of Coxsackie B Virus Infection in Human Pancreatic Islets

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    Effects of immunosuppressive drugs on in vitro neogenesis of human islets: mycophenolate mofetil inhibits the proliferation of ductal cells

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  • Elshebani, Asma; Olsson, Annika; Westman, Jan; Tuvemo, Torsten et al.

    Effects on isolated human pancreatic islet cells after infection with strains of enterovirus isolated at clinical presentation of type 1 diabetes

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  • Gao, Ru; Ustinov, Jarkko; Korsgren, Olle; Mikkola, Milla et al.

    Maturation of in vitro-generated human islets after transplantation in nude mice

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    No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation

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    Positron emission tomography: A real-time tool to quantify early islet engraftment in a preclinical large animal model

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    Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation

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    Lymphocyte propagation from biopsies of kidney allografts

    Part of Transplant Immunology, p. 215-219, 2006.

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    Composite islet-endothelial cell grafts: a novel approach to counteract innate immunity in islet transplantation.

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    Current status of clinical islet transplantation.

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    Inflammatory gene expression in Coxsackievirus B-4-infected human islets of Langerhans.

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    Key factors for human islet isolation and clinical transplantation.

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    Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood.

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    Pig islet xenotransplantation: activation of porcine endogenous retrovirus in the immediate post-transplantation period

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    Technical improvement of human pancreatic islet isolation.

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    The efficacy of CD40 ligand blockade in discordant pig-to-rat islet xenotransplantation is correlated with an immunosuppressive effect of immunoglobulin.

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    The recent finding that tissue factor is produced by the pancreatic islets constitutes a possible link between insulin resistance and cardiovascular disease.

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    Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation

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    Adenovirus CD40 Ligand Gene Therapy Counteracts Immune Escape Mechanisms in the Tumor Microenvironment

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  • Wennberg, L; Song, Z; Bennet, W; Sandberg, J O et al.

    Importance of the Gal alpha1-3 Gal antigen in discordant islet xenotransplantation: immunosuppression, which inhibits porcine islet xenograft rejection in ordinary mice, is equally effective in Gal-knockout mice.

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  • Mirza, Bilal; Krook, Henrik; Andersson, Per; Larsson, Lena C et al.

    Intracerebral cytokine profiles in adult rats grafted with neural tissue of different immunological disparity.

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  • Goto, Masafumi; Groth, CG; Nilsson, Bo; Korsgren, Olle

    Intraportal pig islet xenotransplantation into athymic mice as an in vivomodel for the study of the instant blood-mediated inflammatory reaction.

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  • Schmidt, Peter; Krook, Henrik; Goto, Masafumi; Korsgren, Olle

    MyD88-dependent toll-like receptor signalling is not a requirement for fetal islet xenograft rejection in mice

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    Possible transmission of zoonoses in xenotransplantation: porcine endogenous retroviruses (PERVs) from an immunological point of view

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    Refinement of the automated method for human islet isolation and presentation of a closed system for in vitro islet culture

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  • Engstrand, Mats; Lidehäll, Anna Karin; Tötterman, Thomas H.; Herrmann, Björn et al.

    Cellular responses to cytomegalovirus in immunosuppressed patients: circulating CD8+ T cells recognizing CMVpp65 are present but display functional impairment

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  • Gao, Ru; Ustinov, Jarkko; Pulkkinen, Mari-Anne; Lundin, Karolina et al.

    Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture.

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    Intragraft cytokine mRNA expression in rejecting and non-rejecting Vascularised Xenografts

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  • Moberg, Lisa; Olsson, Annika; Berne, Christian; Felldin, Marie et al.

    Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation.

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    A distinct Th1 immune response precedes the described Th2 response in Islet xenograft rejection

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    Immunosuppressive drugs in islet xenotransplantation: A tool for gaining further insights in the mechanisms of the rejection process

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    Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation.

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