Johan Rönnelid – Immune complexes in rheumatic diseases
Our research focuses on the functional and prognostic impact of immune complexes and immune complex-associated autoantibodies in rheumatic diseases and chronic infections.
We study immune complex (IC)-mediated mechanisms in chronic rheumatic diseases, primarily rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) We also study how IC and IC-associated autoantibodies act as prognostic markers for future disease development. We also perform clinical and immunological comparative studies between Sweden, Asia (Malaysia) and Africa (Sudan).
Our research aims to make IC more central in the etiologic perception of chronic diseases from a modernized functional approach. This can lead to definition of new IC-dependent disease phenotypes, as has been the case in RA, as well as to phenotype-based therapies in autoimmune diseases with IC-driven pathology.