Archive: Picture of the week
Here you can find previous pictures of the week.
Dysfunctional roads and loss of the lymphocyte guiding road signs in tumor draining lymph nodes
By Tove Bekkhus
20 January, 2021
Vectra Polaris image of remodeled (i.e. dilated) high endothelial venules (HEVs) (white) and perivascular fibroblastic reticular cells (FRCs) (green) with disrupted immobilization of the T-lymphocyte attracting chemokine CCL21 (magenta) resulting in accumulation of CCL21 saturated lymphocytes (magenta). Picture taken from a lymph node draining the malignant breast cancer tumor; invasive ductal carcinoma.
A super thin forgotten cell
By Johanna Andrae
28 August, 2020
Confocal microscope image of a blood vessel in the meninges outside the brain – cell nuclei (blue), perivascular fibroblasts (green), endothelial cells (white), extracellular matrix (red).
Colored-coded clones to study vascular malformations
By Hans Schoofs
2 July, 2020
Confocal microscope image of mouse ear skin showing clonally labelled endothelial cells (nuclei are stochastically labeled green, red or cyan) in blood vessels (gray) or lymphatic vessels (yellow).
When lymphatic vessels go crazy
By Ines Martinez-Corral
8 June, 2020
Confocal microscope image of a microcystic lymphatic malformation growing in the ear skin of an adult mouse. Lymphatic vessels are observed in green. The picture was taken from a mouse model in which a disease causative PIK3CAH1047R mutation is expressed specifically in lymphatic endothelia.
LET´s play MARCO polo in the LECs pool
By Ruben Grosso
25 May, 2020
Fluorescent labelling of lymphatic endothelial cell (LEC) populations in a mouse inguinal lymph node (LN). All LECs share expression of the pan LEC marker PROX1 (blue). The lymphatic marker LYVE1 (red) mark the floor of the subcapsular sinus (SCS) (fLECs) and major areas of the paracortical and medullary sinuses while the ceiling of the SCS (cLECs) is negative. MARCO-LECs are distinguished from other LN LECs by their high expression of the scavenger receptor Macrophage Receptor with Collagenous Structure (MARCO) (green). MARCO staining delineates medullary sinuses adjacent to the B cell follicles in the LN (peri-follicular sinuses).
Following the path
By Roberta Lugano
11 May, 2020
Confocal image of murine glioma cells (red) migrating along blood vessels (green) in an ex-vivo murine brain slice model.
Cerebral Cavernous Malformations: an endothelial tumor?
By Matteo Malinverno
27 April, 2020
Confocal image of a cerebral cavernoma developed by clonal expansion of mutated endothelial cells (red).
We’re in! Where to go now?
By Miguel Sáinz-Jaspeado
14 April, 2020
Confocal image of tumor cells (red) using a lymphatic vessel (green) as a gateway to metastasize in the dermis of a mouse ear.
The funambulist gatekeeper
By Elisa Vasquez
6 April, 2020
Confocal microscope image of a pericyte (cyan) stretching out in an attempt to cover two adjacent capillaries (magenta) in the brain. This picture is taken from a pericyte deficient mouse model and would be an unusual sight in a healthy brain where virtually all blood vessels are covered by pericytes.
Maintenance work in progress
By Mehran Hariri
30 March, 2020
Confocal microscope image of DNA double-strand breakage repair sites (bright green and orange) in ovarian cancer cell nuclei (blue) after exposure to the chemotherapy drugs Cisplatin and Onalespib.
Spider webs in the lung?
By Leonor Gouvveia
23 March, 2020
Confocal microscope image of an adult mouse lung showing the alveolar elastin network (grey) and cell nuclei (blue).
Zip up and follow my lead
By Di Peng
16 March, 2020
Confocal microscopic image of developing blood vessels which extend spiky protrusions to sense the environment. This example from a developing zebrafish embryo shows how endothelial cells - the building blocks of blood vessels – stay connected via zipper-like cell-cell junctions.
Traffic jam at the intersection
By Alberto Alberto Álvarez-Aznar
9 March, 2020
Confocal microscope image of red blood cells (green) inside venous blood vessels on their way back to the heart (magenta).