Student projects at IGP

IGP offers projects for students at different education programmes. Below you can find summaries of projects that are available at the moment in different research areas.

Click on the title to get to a longer description and to find contact information for the supervisor of the project. For further details about how to register for a project, please contact the supervisor.
                                      

         
 Photo: Magnus Hjalmarsson

Projects

Cancer/oncology

  

Vascular biology

The role of the lymph node vasculature in tumour metastasis and anti-tumour immunity
The lymph nodes have essential roles in adaptive immune responses, including anti-tumour immune responses, and are major sites for tumour metastasis. Our group is interested in the stromal changes that occur in the tumour draining lymph nodes and particularly the changes of the vasculature and how this affect tumour metastasis and anti-tumour immune responses.

Investigating new immunotherapy combinations for the treatment of bladder cancer
Localized bladder cancer can be treated with locally administrated BCG or chemotherapy delivered into the bladder lumen. However tumor recurrence is high for both local and metastatic disease. Our research focuses on studying how combinations of locally administrated immunotherapies can aid a systemic anti-tumor response so that metastatic disease is also prevented.

Investigating adaptive immune responses in human whole blood
Efficacy, toxicity and cytokine release are parameters important to study with novel immunotherapies. This project will modify/improve existing methods in order to advance the field of cytokine release/immune toxicity technologies. Techniques that will be used are flow cytometry, Q-PCR and ELISA based technologies.

Clinical or translational research on adult cancer cases in U-CAN
Clinical data gathering or sample analyses based on the cancer cases included in U-CAN followed by hypothesis testing.

Extracellular matrix interactions of importance for brain tumour formation and neural development
In our projects we incorporate experience of neural stem cells with glioma biology, leveraging the close relationship between these two fields. We also investigate the neuro-inflammatory responses to brain tumours.

Investigations of cancer stem cells in the brain cancer glioblastoma
Glioblastoma is the most common and deadly primary brain cancer. Our research aims at identifying mechanisms governing progression and recurrence, with focus on the cancer stem cells. We use patient-derived cell cultures and mouse models, and the goal is to find novel therapeutic targets in glioblastoma.

Finding and understanding somatic mutations and their contribution to development of colorectal cancer
We are looking for students with an interest in functional studies or genetics of cancer, or in development of computer tools for large sequence data analysis.

New treatment for brain tumors: Sensitization of multi-resistant glioblastoma clones
Gliobastoma multiforme is the most malignant primary brain tumor. The cancer cells vary between more treatment-resistant and more treatment-sensitive cell-states.  Current studies aim to uncover forces that drives these changes in treatment resistance and make all cells vulnerable to therapy.

       

The role of Tie2 signalling in kidney fibrosis
The project involves the vascular factor Tie2 and how it affects the development of fibrosis in kidney. You will have the opportunity to learn tissue dissection, immunofluorescence staining, confocal imaging, image analysis and molecular biology, including RNA preparation and real time PCR.
 

Deciphering the cellular effects of edema on the vasculature
The project tests the hypothesis that increased interstitial pressure leads to specific cytoskeletal and junctional rearrangements in endothelial cells to adjust the balance between vascular leakage and lymphatic drainage, which is prerequisite for normal vascular development and function.

Elucidating organ-specific mechanisms of development and disease within the lymphatic vasculature
The project investigates mechanisms of lymphatic vascular development in different organs and provides insight into tissue-specific functional specialization and disease manifestation within the vasculature. We focus on characterizing organ-specific endothelial progenitor cells using genetic mouse models, microscopy and single-cell transcriptomics.

Molecular Tools

New approaches for molecular diagnostics
Molecular diagnostics will increasingly impact medical practice. Our group develops, applies, and disseminates advanced molecular tools for diagnostic analyses of nucleic acids and proteins in situ and in solution. We welcome students interested in helping us expand the range of molecular analyses possible, or find compelling biomedical applications of these methods.

Methods for RNA and protein analysis in single cells
The Molecular Tools group and the SciLifeLab Single Cell Proteomics Facility are developing methods to study RNA and protein in multiplex at the level of the single cell.

 

Genetics and genomics



Pathology



Diabetes



Immunology