The role of the lymph node vasculature in tumour metastasis and anti-tumour immunity
The lymph nodes have essential roles in adaptive immune responses, including anti-tumour immune responses, and are major sites for tumour metastasis. Our group is interested in the stromal changes that occur in the tumour draining lymph nodes and particularly the changes of the vasculature and how this affect tumour metastasis and anti-tumour immune responses.
Investigating new immunotherapy combinations for the treatment of bladder cancer
Localized bladder cancer can be treated with locally administrated BCG or chemotherapy delivered into the bladder lumen. However tumor recurrence is high for both local and metastatic disease. Our research focuses on studying how combinations of locally administrated immunotherapies can aid a systemic anti-tumor response so that metastatic disease is also prevented.
Investigating adaptive immune responses in human whole blood
Efficacy, toxicity and cytokine release are parameters important to study with novel immunotherapies. This project will modify/improve existing methods in order to advance the field of cytokine release/immune toxicity technologies. Techniques that will be used are flow cytometry, Q-PCR and ELISA based technologies.
Clinical or translational research on adult cancer cases in U-CAN
Clinical data gathering or sample analyses based on the cancer cases included in U-CAN followed by hypothesis testing.
Extracellular matrix interactions of importance for brain tumor formation and neural development
In our projects we incorporate experience of neural stem cells with glioma biology, leveraging the close relationship between these two fields. We also investigate the neuro-inflammatory responses to brain tumors.
Investigations of cancer stem cells in the brain cancer glioblastoma
Glioblastoma is the most common and deadly primary brain cancer. Our research aims at identifying mechanisms governing progression and recurrence, with focus on the cancer stem cells. We use patient-derived cell cultures and mouse models, and the goal is to find novel therapeutic targets in glioblastoma.
Exploiting loss of heterozygosity for cancer chemotherapy
As an alternative to the anti-cancer therapeutic strategies already established in the clinic, we propose a conceptually different approach where human genetic variation and the cancer-specific phenomenon of loss of heterozygosity (LOH) are exploited.
Screening for new treatments to target MYC proteins in childhood brain tumor relapse models
In this project we evaluate new epigenetic drugs and drugs that target specific cancer proteins for their potential in treating highly malignant childhood brain tumors. We correlate drug efficacy with standard care in stem cell models and in patient-derived cells.
Analyzing PDGF in tracheal aspirates from premature babies
This project is a pilot study to work out methods to prepare RNA/DNA/proteins/cells from tracheal aspirates from premature babies. The tracheal aspirates are obtained daily in the clinic and normally goes to waste. We want to work out methods to use these samples for measurement of different markers.
Investigation of new developmental sources and genes controlling the lymphatic vasculature in development and disease
The project involves isolation of different types of lymphatic endothelial and progenitor cells for transcriptional profiling. You will have the opportunity to learn tissue dissection, whole mount immunofluorescence and confocal imaging and molecular biology, including RNA preparation and real time PCR.
The role of Tie2 signalling in kidney fibrosis
The project involves the vascular factor Tie2 and how it affects the development of fibrosis in kidney. You will have the opportunity to learn tissue dissection, immunofluorescence staining, confocal imaging, image analysis and molecular biology, including RNA preparation and real time PCR.
New approaches for molecular diagnostics
Molecular diagnostics will increasingly impact medical practice. Our group develops, applies, and commercializes advanced molecular tools for diagnostic analyses of nucleic acids and proteins in situ and in solution. We welcome students interested in medical applications of the methods.
Methods for RNA and protein analysis in single cells
The Molecular Tools group and the SciLifeLab Single Cell Proteomics Facility are developing methods to study RNA and protein in multiplex at the level of the single cell.
Genetics and genomics
Novel therapeutic strategies in neurocristopathies using induced pluripotent stem cell (iPSC) technology
Neurocristopathies are genetic disorders caused by defects in neural crest development. In the project, a model for studying molecular mechanisms underlying two forms of neurocristopathy in vitro will be established using induced pluripotent stem cells and directed neural differentiation.