Mats Hellström – Characterization of Novel Regulators of Blood Vessel Formation

Increased understanding of how the formation of new blood vessels is regulated may lead to the development of new or improved disease therapies.

In recent years scientists have clarified how important the formation of new blood vessels is in various diseases. Despite this fact, there is still a lack of knowledge about the signalling pathways that regulate blood vessel formation and only a few blood vessel-specific drugs have been developed.

Our research focuses on finding signalling components that are specific for endothelial cells, the cells that line the inner walls of blood vessels. We have identified several possible candidates and one of these, called paladin, we have analysed in more detail. We have shown that mice that lack paladin have altered blood vessels in the retina, and we are studying the role of paladin in tumour development.

Paladin belongs to a group of proteins that are commonly involved in cell signalling. We hope that our results will contribute to an increased understanding of signalling during the formation of new blood vessels in tumours.
 

Read more about our research