Experimental and clinical oncology

Our overall goal is to gain insight into the complex molecular mechanisms underlying tumour evolution, and to identify novel prognostic and/or predictive markers and treatment targets. In addition, the consequences of the disease and treatment for the physical, mental and social dimensions of patients’ wellbeing are investigated. 

The research programme includes experimental projects that are performed in the laboratory. Using modern molecular and cellular methods, we study patient derived tumour cells and relevant models for the tumour in vitro and in vivo, to identify essential pathways that may cause cancer or that will affect disease progression. We also want to find novel biomarkers that can be used for improved diagnostics and prognostication, or that may function as targets for new treatment strategies.

Our clinical research programme includes thorough evaluation of the effect of different treatment strategies, to find ways to determine which therapy is most efficient for the individual patients. New treatment modalities, including immunotherapy, are also studied. With the aim to improve immediate patient care, we also study the effects of interventions to diminish treatment toxicity and improve health related quality of life.


 

Research groups

Tumour biology and clinical parameters for diffuse large B-cell lymphoma – Gunilla Enblad

Colorectal cancer – Bengt Glimelius

Characterization of novel regulators of blood vessel formation – Mats Hellström

Molecular characterization of acute leukemia – Linda Holmfeldt

The control of survival and apoptosis in human multiple myeloma – Helena Jernberg Wiklund

Caring sciences in oncology care – Birgitta Johansson

Prognostic and predictive factor in advance cancer in the airways or kidneys – Magnus Lindskog

Individualised, more efficient cancer therapy – Peter Nygren

Molecular hematology; Chronic Lymphocytic Leukemia – Richard Rosenquist Brandell

Molecular cancer genetics – Tobias Sjöblom

Translational immunotherapy – Gustav Ullenhag

 

Photo: bottles with blue cap